English 
中文 
参考文献
[1] Roberts JM, Gammill HS. Preeclampsia: recent insights. Hypertension. 2005 Dec;46(6):1243-9. doi: 10.1161/01.HYP.0000188408.49896.c5. Epub 2005 Oct 17. PMID: 16230510.
[2] Zeisler H, Llurba E, Chantraine F, Vatish M, Staff AC, Sennström M, Olovsson M, Brennecke SP, Stepan H, Allegranza D, Dilba P, Schoedl M, Hund M, Verlohren S. Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia. N Engl J Med. 2016 Jan 7;374(1):13-22. doi: 10.1056/NEJMoa1414838. PMID: 26735990.
[3] Redman CW, Sargent IL. Latest advances in understanding preeclampsia. Science. 2005 Jun 10;308(5728):1592-4. doi: 10.1126/science.1111726. PMID: 15947178.
[4] Roberts, J M, and C A Hubel. “The two stage model of preeclampsia: variations on the theme.” Placenta vol. 30 Suppl A,Suppl A (2009): S32-7. doi:10.1016/j.placenta.2008.11.009
[5] Phipps EA, Thadhani R, Benzing T, Karumanchi SA. Pre-eclampsia: pathogenesis, novel diagnostics and therapies. Nat Rev Nephrol. 2019 May;15(5):275-289. doi: 10.1038/s41581-019-0119-6. Erratum in: Nat Rev Nephrol. 2019 Jun;15(6):386. PMID: 30792480; PMCID: PMC6472952.
[6] Chaiworapongsa T, Chaemsaithong P, Yeo L, Romero R. Pre-eclampsia part 1: current understanding of its pathophysiology. Nat Rev Nephrol. 2014 Aug;10(8):466-80. doi: 10.1038/nrneph.2014.102. Epub 2014 Jul 8. PMID: 25003615; PMCID: PMC5893150.
[7] Guo Z, Yang F, Zhang J, Zhang Z, Li K, Tian Q, Hou H, Xu C, Lu Q, Ren Z, Yang X, Lv Z, Wang K, Yang X, Wu Y, Yang X. Whole-Genome Promoter Profiling of Plasma DNA Exhibits Diagnostic Value for Placenta-Origin Pregnancy Complications. Adv Sci (Weinh). 2020 Feb 18;7(7):1901819. doi: 10.1002/advs.201901819. PMID: 32274292; PMCID: PMC7141029.
[8] Moufarrej MN, Vorperian SK, Wong RJ, Campos AA, Quaintance CC, Sit RV, Tan M, Detweiler AM, Mekonen H, Neff NF, Baruch-Gravett C, Litch JA, Druzin ML, Winn VD, Shaw GM, Stevenson DK, Quake SR. Early prediction of preeclampsia in pregnancy with cell-free RNA. Nature. 2022 Feb;602(7898):689-694. doi: 10.1038/s41586-022-04410-z. Epub 2022 Feb 9. PMID: 35140405; PMCID: PMC8971130.
[9] Zeisler H, Llurba E, Chantraine FJ, Vatish M, Staff AC, Sennström M, Olovsson M, Brennecke SP, Stepan H, Allegranza D, Schoedl M, Grill S, Hund M, Verlohren S. Soluble fms-like tyrosine kinase-1 to placental growth factor ratio: ruling out pre-eclampsia for up to 4 weeks and value of retesting. Ultrasound Obstet Gynecol. 2019 Mar;53(3):367-375. doi: 10.1002/uog.19178. Epub 2019 Feb 4. PMID: 30014562; PMCID: PMC6590225.
[10] Chaemsaithong P, Sahota DS, Poon LC. First trimester preeclampsia screening and prediction. Am J Obstet Gynecol. 2022 Feb;226(2S):S1071-S1097.e2. doi: 10.1016/j.ajog.2020.07.020. Epub 2020 Jul 16. PMID: 32682859.
[11] O'Gorman N, Wright D, Poon LC, Rolnik DL, Syngelaki A, de Alvarado M, Carbone IF, Dutemeyer V, Fiolna M, Frick A, Karagiotis N, Mastrodima S, de Paco Matallana C, Papaioannou G, Pazos A, Plasencia W, Nicolaides KH. Multicenter screening for pre-eclampsia by maternal factors and biomarkers at 11-13 weeks' gestation: comparison with NICE guidelines and ACOG recommendations. Ultrasound Obstet Gynecol. 2017 Jun;49(6):756-760. doi: 10.1002/uog.17455. Erratum in: Ultrasound Obstet Gynecol. 2017 Dec;50(6):807. PMID: 28295782.
[12] Odibo AO, Goetzinger KR, Odibo L, Cahill AG, Macones GA, Nelson DM, Dietzen DJ. First-trimester prediction of preeclampsia using metabolomic biomarkers: a discovery phase study. Prenat Diagn. 2011 Oct;31(10):990-4. doi: 10.1002/pd.2822. Epub 2011 Jul 11. PMID: 21744367; PMCID: PMC3713070.
[13] Bahado-Singh RO, Akolekar R, Mandal R, Dong E, Xia J, Kruger M, Wishart DS, Nicolaides K. Metabolomics and first-trimester prediction of early-onset preeclampsia. J Matern Fetal Neonatal Med. 2012 Oct;25(10):1840-7. doi: 10.3109/14767058.2012.680254. Epub 2012 Apr 28. PMID: 22494326.
[14] Austdal M, Tangerås LH, Skråstad RB, Salvesen K, Austgulen R, Iversen AC, Bathen TF. First Trimester Urine and Serum Metabolomics for Prediction of Preeclampsia and Gestational Hypertension: A Prospective Screening Study. Int J Mol Sci. 2015 Sep 8;16(9):21520-38. doi: 10.3390/ijms160921520. PMID: 26370975; PMCID: PMC4613265.
